Customized topography-guided photorefractive keratectomy with the MEL-70 platform and mitomycin C to correct hyperopia after radial keratotomy.

Abstract

PURPOSE:

To evaluate topography-guided photorefractive keratectomy (PRK) for correcting hyperopia and astigmatism after radial keratotomy (RK).

METHODS:

Prospective study of 12 consecutive patients (19 eyes) who were treated with topography-guided PRK with 0.02% mitomycin C using an Asclepion-Meditec MEL-70 excimer laser with a 9.5-mm ablation zone. All eyes were operated by the same surgeon and followed for 1 year.

RESULTS:

Thirteen eyes had complete epithelialization by day 7 and all eyes by day 10. At 1 year, uncorrected visual acuity was 20/25 or better in 42.1% of eyes and 20/40 or better in 68.4%. Preoperative mean spherical equivalent refraction was +3.80+/-2.47 diopters (D) and +0.24+/-2.36 D (P<.001) 1 year postoperative, with 47.4% of eyes being within +/-1.00 D and 73.7% within +/-2.00 D. Preoperative mean cylinder was -2.30+/-1.41 D and -0.62+/-0.73 D (P<.001) 1 year postoperative. At 1 year, 68.4% of eyes gained at least 1 line of best-spectacle corrected visual acuity, 36.8% gained more than 1 line, and only 2 eyes lost 1 line (one due to corneal haze). Three eyes developed central haze. Mean regression from 6 to 12 months in these 3 eyes was +1.83 D and in the remaining 16 eyes was -0.50 D.

CONCLUSIONS:

Topography-guided PRK with mitomycin C was safe and reasonably effective for the treatment of hyperopia after RK.

• Authors: Ramon C Ghanem, Vinicius C Ghanem, Denise C de Souza, Newton Kara-José, Emir A Ghanem
• Journal: Journal of refractive surgery (Thorofare, N.J. : 1995) (J Refract Surg) Vol. 24 Issue 9 Pg. 911-22 (11 2008) ISSN: 1081-597X [Print] United States
• PMID: 19044232 (Publication Type: Journal Article)

Chemical References

• Alkylating Agents
• Mitomycin

Topics

• Adult
• Alkylating Agents (administration & dosage)
• Astigmatism (etiology, surgery)
• Combined Modality Therapy
• Corneal Topography (methods)
• Female
• Follow-Up Studies
• Humans
• Hyperopia (etiology, surgery)
• Intraoperative Complications
• Keratotomy, Radial (adverse effects)
• Lasers, Excimer (therapeutic use)
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Photorefractive Keratectomy (methods)
• Postoperative Complications
• Prospective Studies
• Treatment Outcome
• Visual Acuity (physiology)