Abstract | OBJECTIVES: The purpose of this study was to evaluate cytotoxic activity of Platycladus orientalis, Prangos asperula and Cupressus sempervirens ssp. pyramidalis essential oils and to identify active components involved in inhibition of population growth of human cancer cell lines. MATERIALS AND METHODS: RESULTS: Cupressus sempervirens ssp. pyramidalis leaf oil exerted the highest cytotoxic activity with an IC(50)value of 104.90 microg/mL against C32, followed by activity of P. orientalis and P. asperula on the renal adenocarcinoma cell line (IC(50) of 121.93 and 139.17 microg/mL, respectively). P. orientalis essential oil was also active against amelanotic melanoma with an IC(50) of 330.04 microg/mL. Three identified terpenes, linalool, beta-caryophyllene and alpha- cedrol, were found to be active on both cell lines tested. CONCLUSIONS: Our findings provide novel insights into the field of cytotoxic properties of essential oils. This study provided evidence on how cytotoxic activity of the oils is not always related to their major constituents, except for lower activity found in both cell lines for alpha- cedrol. Interestingly, beta-caryophyllene and linalool exhibited comparable IC(50) values to the commercial drug vinblastine on the ACHN cell line. This opens a new field of investigation to discover mechanisms responsible for the observed activity.
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Authors | M R Loizzo, R Tundis, F Menichini, A M Saab, G A Statti, F Menichini |
Journal | Cell proliferation
(Cell Prolif)
Vol. 41
Issue 6
Pg. 1002-1012
(Dec 2008)
ISSN: 1365-2184 [Electronic] England |
PMID | 19040575
(Publication Type: Journal Article)
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Chemical References |
- Oils, Volatile
- Plant Oils
- Terpenes
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Topics |
- Carcinoma, Renal Cell
(drug therapy, pathology)
- Cell Death
(drug effects)
- Cell Line
- Cell Proliferation
(drug effects)
- Cupressus
(chemistry)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Humans
- Kidney Neoplasms
(drug therapy, pathology)
- Melanoma, Amelanotic
(drug therapy, pathology)
- Oils, Volatile
(chemistry, pharmacology, therapeutic use)
- Phytotherapy
- Plant Oils
(chemistry, pharmacology, therapeutic use)
- Skin Neoplasms
(drug therapy, pathology)
- Terpenes
(pharmacology)
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