A 37 year-old female with
Kallmann syndrome and
NIDDM who had two successful deliveries is reported. She had experienced no menstruation until she had treatment with
gestagen in her early twenties. She had withdrawal
bleeding only once. At the age of 25, she consulted her family doctor, complaining of
amenorrhea.
Estrogen progesterone cyclic
therapy caused withdrawal
bleeding, and
clomiphene citrate failed to induce apparent ovulation. In January 1978, 150 IU of hMG was administered daily for 9 days, and then 3000 IU of hCG daily for the following 2 days. This
therapy induced pregnancy, which failed spontaneously on June 4th. A year later, in January 1979, 150 IU of hMG was again administered daily for 7 days followed by 6000 IU of hCG for 3 days. This
therapy again induced pregnancy. On September 27th, 1979, she delivered a girl vaginally, weighing 3830 g. After this delivery, she experienced no menstruation. In June 1985, she consulted her family doctor again, and she was diagnosed as being pregnant. Since her fasting
blood glucose was 145 mg/dl, she was admitted to Kosei Hospital to control her
blood glucose. On October 15th, she delivered a girl weighing 2600 g. On June 13th, 1989, she was referred to Kosei Hospital by her family doctor to achieve an accurate control of her
blood glucose. During this admission, she was diagnosed as having
Kallmann syndrome because of
congenital anosmia and
hypogonadotropic hypogonadism without any abnormal morphological changes.
Vitamin B1 infusion test was negative.(ABSTRACT TRUNCATED AT 250 WORDS)