Effect of antiparkinsonian drug himantane on the content of dopamine transporter DAT protein in rat striatum and cultured pheochromocytoma PC-12 cells.

Abstract	We studied the effects of antiparkinsonian drug himantane (acute and subchronic administration) on the content of dopamine transporter protein DAT in rat striatum ex vivo and on the content of DTA in cultured PC-12 cells (10(-5) - 10(-7) M, the preparation was added to the incubation medium once or 7 times). The preparation significantly reduced the content of DAT protein both ex vivo and in vitro.
Authors	D A Abaimov, T A Zenina-Antipova, G I Kovalev, S B Seredenin
Journal	Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 145 Issue 3 Pg. 331-3 (Mar 2008) ISSN: 0007-4888 [Print] United States
PMID	19039936 (Publication Type: Journal Article)
Chemical References	Antiparkinson Agents Dopamine Plasma Membrane Transport Proteins N-(2-adamantyl)hexamethylenimine Adamantane
Topics	Adamantane (administration & dosage, analogs & derivatives, pharmacology) Animals Antiparkinson Agents (pharmacology) Corpus Striatum (drug effects, metabolism) Dopamine Plasma Membrane Transport Proteins (metabolism) Male PC12 Cells (metabolism) Rats Rats, Wistar

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