Abstract | OBJECTIVE: To determine if a combination of ferucarbotran-enhanced T2*weighted-gradient echo (T2*W-GRE) and T2-weighted turbo spin echo (T2W-TSE) images in gadolinium- and ferucarbotran-enhanced MRI has additive efficacy compared to each image alone for detecting small (< or = 2.0 cm) hepatocellular carcinoma (HCC) lesions in a group of cirrhotic patients and metastases in a group of non-cirrhotic patients. MATERIALS AND METHODS: Two readers retrospectively analyzed gadolinium- and ferucarbotran-enhanced T2*W-GRE, T2W-TSE, and combined T2*W-GRE/T2W-TSE images of 119 patients with 157 HCCs and 32 patients with 98 metastases. The diagnostic accuracy and sensitivity for each image set and the combined set were evaluated using the alternative-free response receiver operating characteristic method. RESULTS: The mean area under the curve value of the combined set (0.966) tended to be better than that for each individual image set (T2W-TSE [0.910], T2*W-GRE [0.892]). Sensitivities in the combined set were higher than those in each individual image set for detecting HCC (mean, 93.0% versus 81.6% and 86.7%, respectively, p < 0.01). Sensitivities in the combined set and the T2W-TSE set were the same for detecting metastases, and both were higher than the sensitivity seen in the T2*W-GRE set (mean, 97.5% versus 85.2 %, p < 0.01). CONCLUSION: Combining ferucarbotran-enhanced T2*W-GRE and T2W-TSE has additive efficacy for detecting HCC in cirrhotic patients, but T2W-TSE is preferred for detecting metastases in non-cirrhotic patients.
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Authors | Young Kon Kim, Young Hwan Lee, Hyo Sung Kwak, Chong Soo Kim, Young Min Han |
Journal | Korean journal of radiology
(Korean J Radiol)
2008 Nov-Dec
Vol. 9
Issue 6
Pg. 510-9
ISSN: 1229-6929 [Print] Korea (South) |
PMID | 19039267
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Dextrans
- Magnetite Nanoparticles
- Oxides
- Iron
- ferumoxides
- Gadolinium DTPA
- Ferrosoferric Oxide
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Topics |
- Adult
- Aged
- Carcinoma, Hepatocellular
(diagnosis)
- Contrast Media
(administration & dosage)
- Dextrans
- Female
- Ferrosoferric Oxide
- Gadolinium DTPA
- Humans
- Iron
- Liver Neoplasms
(diagnosis, secondary)
- Magnetic Resonance Imaging
(methods)
- Magnetite Nanoparticles
- Male
- Middle Aged
- Observer Variation
- Oxides
- Predictive Value of Tests
- Sensitivity and Specificity
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