Abstract | OBJECTIVES: METHODS: RESULTS: Data were available for analysis from 124 patients. Although the incidence of hot flashes largely tended to be greater in the bicalutamide group than in the chlormadinone group, no significant difference was noted in the cumulative incidence of hot flashes at 2 years. The median frequency of hot flashes daily was 1.3 and 2.2 for warmth/ flushing (P = .16) and 1.0 and 3.6 for sweating (P = .021) in the chlormadinone and bicalutamide groups, respectively. Patients in the chlormadinone group were significantly less likely to be distressed by warmth/ flushing (odds ratio 0.47, P < .001) and sweating (odds ratio 0.61, P = .01) than were those in the bicalutamide group. The Functional Assessment of Cancer Therapy-Prostate scores over time showed no intergroup differences. CONCLUSIONS:
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Authors | Hideki Sakai, Tsukasa Igawa, Toshifumi Tsurusaki, Morishi Yura, Yasuyuki Kusaba, Mikio Hayashi, Shotaro Iwasaki, Hironobu Hakariya, Tanetoshi Hara, Hiroshi Kanetake |
Journal | Urology
(Urology)
Vol. 73
Issue 3
Pg. 635-40
(Mar 2009)
ISSN: 1527-9995 [Electronic] United States |
PMID | 19038426
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Androgen Antagonists
- Anilides
- Antineoplastic Agents, Hormonal
- Nitriles
- Steroids
- Tosyl Compounds
- Chlormadinone Acetate
- Gonadotropin-Releasing Hormone
- bicalutamide
- Leuprolide
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Topics |
- Aged
- Androgen Antagonists
(administration & dosage, adverse effects)
- Anilides
(administration & dosage, adverse effects)
- Antineoplastic Agents, Hormonal
(administration & dosage, adverse effects)
- Chlormadinone Acetate
(administration & dosage, adverse effects)
- Drug Therapy, Combination
- Gonadotropin-Releasing Hormone
(analogs & derivatives)
- Hot Flashes
(etiology)
- Humans
- Leuprolide
(administration & dosage, adverse effects)
- Male
- Nitriles
(administration & dosage, adverse effects)
- Prospective Studies
- Prostatic Neoplasms
(drug therapy)
- Quality of Life
- Steroids
(administration & dosage, adverse effects)
- Tosyl Compounds
(administration & dosage, adverse effects)
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