Abstract | BACKGROUND: Deterioration of peroxisomal beta-oxidation activity causes an accumulation of very long chain saturated fatty acids (VLCSFA) in various organs. We have recently reported that the levels of VLCSFA in the plasma and/or membranes of blood cells were significantly higher in patients with metabolic syndrome and in patients with coronary artery disease than the controls. The aim of the present study is to investigate the effect of VLCSFA accumulation on inflammatory and oxidative responses in VLCSFA-accumulated macrophages derived from X-linked adrenoleukodystrophy ( X-ALD) protein (ALDP)-deficient mice. RESULTS: CONCLUSION: These results suggested that VLCSFA accumulation in macrophages may contribute to the pathogenesis of inflammatory diseases through the enhancement of inflammatory and oxidative responses.
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Authors | Naotake Yanagisawa, Kazunori Shimada, Tetsuro Miyazaki, Atsumi Kume, Yohei Kitamura, Katsuhiko Sumiyoshi, Takashi Kiyanagi, Takafumi Iesaki, Nao Inoue, Hiroyuki Daida |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 7
Pg. 48
(Nov 28 2008)
ISSN: 1476-511X [Electronic] England |
PMID | 19038055
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Fatty Acids
- Interleukin-6
- Lipopolysaccharides
- Reactive Oxygen Species
- Tumor Necrosis Factor-alpha
- Interleukin-12
- Nitric Oxide
- Interferon-gamma
- Nitric Oxide Synthase Type II
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Topics |
- Animals
- Cells, Cultured
- Cytokines
(metabolism)
- Fatty Acids
(metabolism)
- Interferon-gamma
(pharmacology)
- Interleukin-12
(metabolism)
- Interleukin-6
(metabolism)
- Lipopolysaccharides
(pharmacology)
- Macrophages
(drug effects, metabolism)
- Male
- Mice
- Mice, Mutant Strains
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase Type II
(genetics)
- Reactive Oxygen Species
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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