A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study.

The effect of a zinc-containing compound, Polaprezinc, was shown to clinically improve the disease conditions of idiopathic taste disorders with no serious side effects in a well controlled double-blinded clinical study.
The purpose of the present study was to evaluate the efficacy and safety of a zinc-containing compound in the treatment of patients with idiopathic taste disorders, including patients with low serum zinc, by a Good Clinical Practice (GCP)-compliant, randomized, placebo-controlled, double-blind, multi-center clinical study.
A group of 109 patients suffering from taste disorders was assigned into placebo and three treatment groups. Each group of patients was given either placebo (n=28), or 17 mg (n=27), 34 mg (n=26) or 68 mg (n=28) of oral zinc, Polaprezinc preparations, daily for 12 weeks.
The group of patients given 68 mg zinc showed a significant improvement in their gustatory sensitivity compared with the placebo group. The most common side effects observed were increase in serum triglyceride and serum alkaline phosphatase, decrease in serum iron, and some gastrointestinal incidents, although they were not serious.
AuthorsMasafumi Sakagami, Minoru Ikeda, Hiroshi Tomita, Akihiro Ikui, Tsunemasa Aiba, Noriaki Takeda, Akira Inokuchi, Yuichi Kurono, Mitsuyoshi Nakashima, Yuji Shibasaki, Osamu Yotsuya
JournalActa oto-laryngologica (Acta Otolaryngol) Vol. 129 Issue 10 Pg. 1115-20 (Oct 2009) ISSN: 1651-2251 [Electronic] England
PMID19037756 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Ulcer Agents
  • Organometallic Compounds
  • Zinc Compounds
  • polaprezinc
  • Carnosine
  • Zinc
  • Adult
  • Aged
  • Anti-Ulcer Agents (therapeutic use)
  • Carnosine (analogs & derivatives, therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Organometallic Compounds (therapeutic use)
  • Taste Disorders (blood, drug therapy)
  • Young Adult
  • Zinc (blood)
  • Zinc Compounds (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: