[Study of the correlation between the expression level of asparagine synthetase and the outcome of children with acute lymphocytic leukemia].

Abstract

OBJECTIVE:

To determine whether the high level of asparagine synthetase (AS) expression in childhood acute lymphocytic leukemia (ALL) is associated with an inferior prognosis.

METHODS:

AS mRNA level in leukemic cells from 53 newly diagnosed ALL children was measured by real time fluorescent quantitative PCR method. Patients were divided into groups according to their relapse risk and outcome, and the AS expression levels in each group were compared. The survival rates in different AS expressing level groups were estimated and compared.

RESULTS:

The highest level of AS [median 17.25 (2.48-46. 82)] was observed in children failed remission, intermediate level [14.28 (3.20-54.47)] in relapsed children and the lowest level [5.08 (0.84-54.92)] in children with continuous complete remission (CCR) (P<0.05). The AS mRNA level [14.93 (2.48-54.47)] in children with poor outcome (un-remission and relapsed) was significantly higher than that in children in CCR (P<0.01). The two-year estimated disease free survival was much lower in children with high AS expression (53.8%) than in those with low AS expression (84.6%) (P<0.05).

CONCLUSION:

High expression of AS is associated with a poor outcome in ALL children.

• Authors: Chang-ying Luo, Ben-shang Li, Hua Jiang, Long-jun Gu
• Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 29 Issue 7 Pg. 446-9 (Jul 2008) ISSN: 0253-2727 [Print] China
• PMID: 19035175 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aspartate-Ammonia Ligase

Topics

• Adolescent
• Aspartate-Ammonia Ligase (metabolism)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Male
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (enzymology)
• Prognosis