Abstract | BACKGROUND: METHODS: All HSCT patients admitted between January 2001 and May 2006 who experienced ARF, received renal replacement therapy (RRT), and had a vitamin A level drawn were included in this retrospective, descriptive study. Molar ratios of vitamin A and retinol-binding protein (RBP) were calculated to more accurately assess vitamin A status. Nineteen patients met the criteria for this study. RESULTS: At initial testing (generally between days 6 and 10 after initiation of RRT), 17 of the 19 patients had abnormally elevated vitamin A levels for their age. Molar ratios of vitamin A to RBP were elevated in 6 patients at initial testing. Prescribed vitamin A intake information (parenteral and enteral) was available for most patients; all but 3 had an average daily intake greater than 2000 IU/kg over the 30 days prior to RRT initiation. Many patients had symptoms possibly related to vitamin A toxicity, although interpretation of hair, skin, and liver abnormalities are difficult to ascertain in HSCT patients. Seven patients had other findings that may have been associated with vitamin A toxicity. CONCLUSION:
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Authors | Ann Connell Lipkin, Polly Lenssen |
Journal | Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
(Nutr Clin Pract)
2008 Dec-2009 Jan
Vol. 23
Issue 6
Pg. 621-9
ISSN: 0884-5336 [Print] United States |
PMID | 19033221
(Publication Type: Journal Article)
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Chemical References |
- Retinol-Binding Proteins
- Vitamin A
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Topics |
- Acute Kidney Injury
(complications, therapy)
- Adolescent
- Child
- Child, Preschool
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Hypervitaminosis A
(etiology)
- Infant
- Male
- Nutritional Support
- Renal Replacement Therapy
(methods)
- Retinol-Binding Proteins
(metabolism)
- Retrospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Vitamin A
(administration & dosage, adverse effects, blood)
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