[Preparation and antibacterial activity of quaternary ammonium salt monomers].

Abstract

OBJECTIVE:

To prepare three quaternary ammonium salt (QAS) monomers, and to compare their antibacterial activities against four oral bacterial strains.

METHODS:

Three antibacterial monomers [methacryloxyethyl benzyl dimethyl ammonium chloride (DMAE-BC), methacryloxyethyl m-chloro benzyl dimethyl ammonium chloride (DMAE-m-CBC), methacryloxyethyl cetyl dimethyl ammonium chloride (DMAE-CB)] were synthesized according to the general structure of target monomers. Their antibacterial effects were investigated using the broth dilution test on Gram-positive and Gram-negative bacterial strains (Streptococcus mutans, Streptococcus sanguis, Porphyromonas gingivalis, Prevotella melaninogenica ).

RESULTS:

Three different monomers were successfully obtained. All the tested bacterial strains were susceptible to the three monomers, among which DMAE-CB exhibited the lowest minimal inhibitory concentrations (MIC) ranging from 1.2 to 4.8 mg/L.

CONCLUSIONS:

All these three QAS monomers have different antibacterial activities against four oral bacteria strains. The data indicate that DMAE-CB may be a candidate antibacterial agent for oral infectious diseases.

• Authors: Yu-Hong Xiao, Ji-Hua Chen, Ming Fang, Xiao-Dong Xing, Fang Li, Zhi-Guo Chai
• Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology (Zhonghua Kou Qiang Yi Xue Za Zhi) Vol. 43 Issue 6 Pg. 370-3 (Jun 2008) ISSN: 1002-0098 [Print] China
• PMID: 19031791 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Dental Materials
• Quaternary Ammonium Compounds

Topics

• Anti-Bacterial Agents (chemistry, pharmacology)
• Dental Materials (chemistry, pharmacology)
• Microbial Sensitivity Tests
• Quaternary Ammonium Compounds (chemistry, pharmacology)