Alkaloids from roots of Stemona sessilifolia and their antitussive activities.

Abstract

Protostemonamide ( 1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine ( 2), stemospironine ( 4), and maistemonine ( 7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine ( 11) had antitussive activity following i. c. v. administration.

• Authors: Xin-Zhou Yang, Jian-Yu Zhu, Chun-Ping Tang, Chang-Qiang Ke, Ge Lin, Tin-Yan Cheng, John A Rudd, Yang Ye
• Journal: Planta medica (Planta Med) Vol. 75 Issue 2 Pg. 174-7 (Feb 2009) ISSN: 0032-0943 [Print] Germany
• PMID: 19031364 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antitussive Agents
• Azepines
• Plant Extracts
• protostemonamide
• Citric Acid
• 4-Butyrolactone

Topics

• 4-Butyrolactone (analogs & derivatives, chemistry, isolation & purification, therapeutic use)
• Alkaloids (chemistry, isolation & purification, therapeutic use)
• Animals
• Antitussive Agents (chemistry, isolation & purification, therapeutic use)
• Azepines (chemistry, isolation & purification, therapeutic use)
• Citric Acid
• Cough (chemically induced, drug therapy)
• Disease Models, Animal
• Guinea Pigs
• Molecular Structure
• Phytotherapy
• Plant Extracts
• Plant Roots
• Stemonaceae (chemistry)