The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.

The findings of the studies on poly(ADP-ribose) polymerase-1 (PARP-1) have suggested that the enzyme inactivation provides significant protection against systemic or tissue inflammation in animal models. It has also shown that the single-nucleotide polymorphism (Val762Ala) of the PARP-1 causes about 40% decrease of enzyme activity. The aim of this study was to analyze the association of the PARP-1 Val762Ala polymorphism in Turkish patients with rheumatoid arthritis. A total of 128 RA patients and 165 normal controls from the same geographic region were studied and polymerase chain reaction (PCR)-based restriction analysis was used to identify Val762Ala polymorphism of the PARP-1. Association analyses were performed using chi (2) tests. Our results indicated that the distribution of the PARP-1 genotypes and alleles did not differ significantly among subjects with or without RA (P > 0.05). The results of the study indicate that, for our Turkish sample, the V762A polymorphism of the PARP-1 may not be involved in susceptibility to RA, implying that the polymorphism may not function as a candidate gene marker for screening RA patients.
AuthorsIlhan Onaran, Gülçin Tezcan, Levent Ozgönenel, Esra Cetin, Alper Tunga Ozdemir, Gönül Kanigür-Sultuybek
JournalRheumatology international (Rheumatol Int) Vol. 29 Issue 7 Pg. 797-800 (May 2009) ISSN: 1437-160X [Electronic] Germany
PMID19030862 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Genetic Markers
  • PARP1 protein, human
  • Poly(ADP-ribose) Polymerases
  • Valine
  • Alanine
  • Adult
  • Aged
  • Alanine (genetics)
  • Amino Acid Substitution (genetics)
  • Arthritis, Rheumatoid (enzymology, ethnology, genetics)
  • DNA Mutational Analysis
  • Female
  • Gene Frequency (genetics)
  • Genetic Markers (genetics)
  • Genetic Predisposition to Disease (genetics)
  • Genetic Testing
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Poly(ADP-ribose) Polymerases (chemistry, genetics)
  • Polymorphism, Genetic (genetics)
  • Turkey (ethnology)
  • Valine (genetics)

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