Low-dose fixed combination of bisoprolol/hydrochlorothiazide as first line for hypertension: a review of the rationale and clinical evidence.

Abstract

Essential hypertension is a heterogeneous multifactorial disease. Data from the National Health and Nutritional Examination Survey and from the World Health Organization have clearly demonstrated that, worldwide, less than 30% of hypertensive patients are adequately controlled by our currently accepted blood pressure goals. Although monotherapy is often unable to achieve blood pressure goals, the use of fixed low-dose combination drugs as alternative treatment seems to be related to a better antihypertensive efficacy and higher response rates in the low range of doses as the result of complementary mechanisms of antihypertensive effects. Indeed clinical trials have shown that initial low-dose combination therapy is superior as compared with treatment by the stepped-care and the sequential monotherapy approach, while recently, low-dose combination therapy for initial antihypertensive therapy instead of the stepped-care approach or of sequential monotherapy has been recommended. This review summarizes the beneficial effect of low-dose bisoprolol/ hydrochlorothiazide combination in the treatment of patients with stage I and II hypertension.

• Authors: Dimitris P Papadopoulos, Vassilios Papademetriou
• Journal: Angiology (Angiology) 2009 Oct-Nov Vol. 60 Issue 5 Pg. 601-7 ISSN: 1940-1574 [Electronic] United States
• PMID: 19028769 (Publication Type: Journal Article, Review)

Chemical References

• Adrenergic beta-Antagonists
• Antihypertensive Agents
• Diuretics
• Drug Combinations
• Hydrochlorothiazide
• Bisoprolol

Topics

• Adrenergic beta-Antagonists (administration & dosage)
• Animals
• Antihypertensive Agents (administration & dosage)
• Bisoprolol (administration & dosage)
• Blood Pressure (drug effects)
• Diuretics (administration & dosage)
• Drug Combinations
• Evidence-Based Medicine
• Humans
• Hydrochlorothiazide (administration & dosage)
• Hypertension (drug therapy, physiopathology)
• Practice Guidelines as Topic
• Severity of Illness Index
• Treatment Outcome