Antibacterial activity of cefditoren against major community-acquired respiratory pathogens recently isolated in Italy.

Abstract

In this study we evaluated the in vitro activities of cefditoren--a broad-spectrum oral cephalosporin--and other comparator agents against 2,396 fresh isolates from community-acquired respiratory tract infections, collected from 6 clinical Italian microbiology laboratories. On penicillin-susceptible pneumococci and Streptococcus pyogenes, cefditoren demonstrated to be the most active antibiotic (MIC(90)values of 0.03 and 0.06 mg/L respectively), showing only a slight decrease in potency on penicillin-intermediate and resistant pneumococci (MIC(90)value 0.5 mg/L, 1.0 mg/L respectively). All the other comparators displayed MIC(90 )values of 4 - 8 mg/L for penicillins and of 4 to >64 mg/L for the oral cephalosporins. Cefditoren and levofloxacin were the most active against MSSA (MIC(90)0.5 mg/mL). Cefditoren displayed a uniformly potent inhibitory activity (MIC(90)of 0.03 mg/L) against all strains of Haemophilus influenzae, regardless of their ampicillin resistance (mediated or not by beta-lactamase production), while against Moraxella catarrhalis MIC(90)values were higher against beta-lactamase-positive (0.25 mg/L). Cefditoren was active also against Klebsiella pneumoniae and Escherichia coli : in this case its activity was comparable with that of levofloxacin. In conclusion, cefditoren, due to its potent activity, is a new effective therapeutic option for the treatment of respiratory tract infections.

• Authors: S Stefani, M L Mezzatesta, G Fadda, R Mattina, G Palù, F Rossano, M A Tufano, G C Schito, G Nicoletti
• Journal: Journal of chemotherapy (Florence, Italy) (J Chemother) Vol. 20 Issue 5 Pg. 561-9 (Oct 2008) ISSN: 1973-9478 [Electronic] England
• PMID: 19028617 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• cefditoren

Topics

• Anti-Bacterial Agents (pharmacology)
• Cephalosporins (pharmacology)
• Community-Acquired Infections (drug therapy, microbiology)
• Haemophilus influenzae (drug effects)
• Humans
• Italy
• Klebsiella pneumoniae (drug effects)
• Microbial Sensitivity Tests
• Moraxella catarrhalis (drug effects)
• Respiratory Tract Infections (drug therapy, microbiology)
• Streptococcus pneumoniae (drug effects)
• Streptococcus pyogenes (drug effects)