Abstract | BACKGROUND:
Ethyl pyruvate (EP) is capable of significantly decreasing serum alanine aminotransferase and reducing hepatic necrosis in a murine model of severe acute pancreatitis (SAP); however, the working mechanism is still unclear. This study aims to elucidate the underlying mechanism of EP solution ameliorating SAP-induced liver injury and provide a new therapeutic agent to treat liver injury. MATERIALS AND METHODS: RESULTS: CONCLUSION: EP is a potent anti-inflammatory and anti-oxidative agent to ameliorate hepatic local inflammatory response and resultantly decreases liver injury secondary to SAP.
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Authors | Runkuan Yang, Angel L Shaufl, Meaghan E Killeen, Mitchell P Fink |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 153
Issue 2
Pg. 302-9
(May 15 2009)
ISSN: 1095-8673 [Electronic] United States |
PMID | 19027919
(Publication Type: Journal Article)
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Chemical References |
- HMGB1 Protein
- Hypoxia-Inducible Factor 1
- Interleukin-6
- NF-kappa B
- Pyruvates
- RNA, Messenger
- Tumor Necrosis Factor-alpha
- ethyl pyruvate
- Malondialdehyde
- Nitric Oxide Synthase Type II
- Nos2 protein, mouse
- Heme Oxygenase-1
- Ptgs2 protein, mouse
- Cyclooxygenase 2
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Topics |
- Animals
- Apoptosis
(drug effects)
- Blood Volume
(drug effects)
- Cyclooxygenase 2
(metabolism)
- HMGB1 Protein
(metabolism)
- Heme Oxygenase-1
(metabolism)
- Hypoxia-Inducible Factor 1
(metabolism)
- Interleukin-6
(metabolism)
- Lipid Peroxidation
- Liver
(metabolism)
- Liver Diseases
(etiology, metabolism, prevention & control)
- Male
- Malondialdehyde
(metabolism)
- Mice
- Mice, Inbred C57BL
- NF-kappa B
(metabolism)
- Nitric Oxide Synthase Type II
(metabolism)
- Pancreatitis, Acute Necrotizing
(complications)
- Pyruvates
(pharmacology, therapeutic use)
- RNA, Messenger
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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