11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents.

Abstract

A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC(50) values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest.

• Authors: Raed A Al-Qawasmeh, Yoon Lee, Ming-Yu Cao, Xiaoping Gu, Stéphane Viau, Jeff Lightfoot, Jim A Wright, Aiping H Young
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 19 Issue 1 Pg. 104-7 (Jan 01 2009) ISSN: 1464-3405 [Electronic] England
• PMID: 19027297 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Dibenzazepines

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Cell Cycle (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Dibenzazepines (chemical synthesis, pharmacology)
• Drug Screening Assays, Antitumor
• G1 Phase
• Humans
• Inhibitory Concentration 50
• Resting Phase, Cell Cycle
• Structure-Activity Relationship