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Inhaled nitric oxide and neuroprotection in preterm infants.

Abstract
Although inhaled nitric oxide-mediated decreases in chronic lung disease and severe intraventricular hemorrhage/periventricular leukomalacia undoubtedly contribute to improved neurodevelopmental outcomes, inhaled nitric oxide has an independent neuroprotective effect. Although these data are encouraging, additional studies are required before recommending the routine use of inhaled nitric oxide for neuroprotection in preterm infants.
AuthorsJeremy D Marks, Michael D Schreiber
JournalClinics in perinatology (Clin Perinatol) Vol. 35 Issue 4 Pg. 793-807, viii (Dec 2008) ISSN: 1557-9840 [Electronic] United States
PMID19026341 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Neuroprotective Agents
  • Nitric Oxide
Topics
  • Administration, Inhalation
  • Central Nervous System Diseases (prevention & control)
  • Heart (drug effects)
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Lung (drug effects)
  • Nervous System (drug effects, growth & development)
  • Neuroprotective Agents (administration & dosage, therapeutic use)
  • Nitric Oxide (administration & dosage, therapeutic use)

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