Gonadotropin-releasing hormone agonist improves the efficiency of controlled ovarian hyperstimulation/intrauterine insemination.

Abstract

OBJECTIVE:

Leuprolide acetate (LA) has improved the efficiency of human menopausal gonadotropins (hMG) in in vitro fertilization cycles. We hypothesized that the combination of LA/hMG/intrauterine insemination (IUI) would be more efficacious than hMG/IUI cycles.

DESIGN:

During an 18-month period, all patients completing either a hMG/IUI cycle (group I) or a LA/hMG/IUI cycle (group II) had the characteristics and outcomes of their stimulation cycles assessed. The groups were not prospectively randomized.

SETTING:

Referral center at a tertiary care hospital.

PATIENTS:

One hundred twenty three patients in group I completed 219 cycles, and 64 patients in group II completed 102 cycles. Twenty-eight of the patients who failed to conceive with hMG/IUI were advanced to group II.

MAIN OUTCOME MEASURES:

Pregnancy/IUI is compared between the two groups.

RESULTS:

Group II demonstrated significantly greater clinical pregnancy/IUI than group I (26.5% and 16.0%, respectively, P less than 0.05), as well as a higher live birth/IUI (21.6% and 12.8%, respectively, P less than 0.05). No difference was present in the rate of fetal wastage or multiple births.

CONCLUSIONS:

In our patients with recalcitrant infertility, the addition of a gonadotropin-releasing hormone agonist to hMG/IUI improved the pregnancy rate, without increasing the rate of multiple births or fetal wastage.

• Authors: C L Gagliardi, A M Emmi, G Weiss, C L Schmidt
• Journal: Fertility and sterility (Fertil Steril) Vol. 55 Issue 5 Pg. 939-44 (May 1991) ISSN: 0015-0282 [Print] United States
• PMID: 1902421 (Publication Type: Journal Article)

Chemical References

• Gonadotropin-Releasing Hormone
• Menotropins
• Leuprolide

Topics

• Female
• Gonadotropin-Releasing Hormone (administration & dosage, analogs & derivatives, therapeutic use)
• Humans
• Infertility (etiology, therapy)
• Insemination, Artificial (methods)
• Leuprolide
• Male
• Menotropins (administration & dosage, therapeutic use)
• Ovary (physiology)
• Pregnancy
• Pregnancy, Multiple