Effect of picrotoxin on organism's resistance to acute severe hypoxia.

Abstract

Organism's resistance to acute severe hypoxia (3% O2) was studied after administration of GABA(A) receptor antagonist picrotoxin and adenosine receptor antagonist euphylline (aminophylline) and after neutralization of secondary hypocapnia by adding 7% CO2 to the hypoxic mixture. Administration of picrotoxin to anesthetized rats increased animal resistance to hypoxia. The resistance to hypoxia decreased after treatment with euphylline. Neutralization of secondary hypocapnia by adding 7% CO2 to the hypoxic mixture had no effect on animal lifespan.

• Authors: N V Sanotskaya, D D Matsievskii, M A Lebedeva
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 145 Issue 2 Pg. 177-80 (Feb 2008) ISSN: 0007-4888 [Print] United States
• PMID: 19023962 (Publication Type: Journal Article)

Chemical References

• Bronchodilator Agents
• GABA Antagonists
• Receptors, GABA-A
• Picrotoxin
• Aminophylline

Topics

• Aminophylline (pharmacology)
• Animals
• Bronchodilator Agents (pharmacology)
• GABA Antagonists (pharmacology)
• Hemodynamics (drug effects)
• Hypocapnia
• Hypoxia
• Male
• Picrotoxin (pharmacology)
• Rats
• Receptors, GABA-A (metabolism)
• Respiration (drug effects)