Abstract | BACKGROUND: METHODS: In a prospective double-blind, randomized, placebo-controlled study, we investigated the analgesic effect of a single dose of parecoxib 40 mg given at dural closure in 82 patients undergoing elective craniotomies. Remifentanil was used intraoperatively, and i.v. morphine was titrated to the requirement in the post-anaesthetic unit. On the ward, i.m. morphine 5 mg as required and regular acetaminophen was prescribed. Morphine use and visual analogue pain scores were recorded at 1, 6, 12, and 24 h after surgery. RESULTS:
Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation. However, overall, it had only minimal impact on postoperative analgesia. We found a wide variability in analgesic requirements where 11% of patients required no opioids and 16% required more than 15 mg i.v. morphine 1 h after the surgery. CONCLUSIONS:
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Authors | S J Jones, J Cormack, M A Murphy, D A Scott |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 102
Issue 1
Pg. 76-9
(Jan 2009)
ISSN: 1471-6771 [Electronic] England |
PMID | 19022794
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Cyclooxygenase 2 Inhibitors
- Isoxazoles
- Morphine
- parecoxib
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Topics |
- Adolescent
- Adult
- Aged
- Analgesics, Opioid
(administration & dosage)
- Craniotomy
(adverse effects)
- Cyclooxygenase 2 Inhibitors
(therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Humans
- Isoxazoles
(therapeutic use)
- Male
- Middle Aged
- Morphine
(administration & dosage)
- Pain Measurement
(methods)
- Pain, Postoperative
(etiology, prevention & control)
- Prospective Studies
- Young Adult
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