Abstract | OBJECTIVE: PATIENTS AND METHODS: In a prospective, randomized, double-arm study, 200 patients were randomized to receive PNB alone (group A, 100) or PNB combined with a previous administration of the topical anaesthetic Antrolin (group B, 100). The PNB was applied by infiltrating bilaterally a solution of 5 mL lidocaine 1% and naropine 0.75%. Patients were asked to complete visual analogue scale (VAS) questionnaire (0-10) to score pain and discomfort during probe insertion (VAS1), PNB (VAS2), cores (VAS3), 30 min after biopsy (VAS4), the evening of the procedure (VAS5), and the day after biopsy (VAS6). RESULTS:
Pain during probe insertion in group B was significantly less than in group A (VAS1 0.82 vs 2.9; P < 0.001). Pain during periprostatic infiltration was also lower in group B than group A (VAS2 1.4 vs 3.48; P < 0.001). Pain control was similar during biopsy in the two groups (VAS3 1.28 vs 1.2; P = 0.69). The pain scored at VAS4 was significantly less in group B (0.7 vs 1.86, P < 0.001), as was VAS5 (0.68 vs 1.3, P < 0.001). There was no difference in pain perception the day after biopsy (VAS6, 0.32 vs 0.22, P = 0.14). CONCLUSIONS:
Antrolin placed with PNB is better than PNB alone in reducing pain and discomfort during transrectal-ultrasonography guided prostate biopsy.
|
Authors | Francesco Cantiello, Vittorio Imperatore, Mariateresa Iannuzzo, Gennaro Scibelli, Sergio Di Meo, Ferdinando Fusco, Ciro Imbimbo, Vincenzo Mirone |
Journal | BJU international
(BJU Int)
Vol. 103
Issue 9
Pg. 1195-8
(May 2009)
ISSN: 1464-410X [Electronic] England |
PMID | 19021624
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Anesthetics, Local
- Neuromuscular Depolarizing Agents
- Lidocaine
- Nifedipine
|
Topics |
- Aged
- Anesthetics, Local
(administration & dosage)
- Biopsy, Needle
(adverse effects)
- Drug Therapy, Combination
- Epidemiologic Methods
- Humans
- Lidocaine
(administration & dosage)
- Male
- Middle Aged
- Nerve Block
(methods)
- Neuromuscular Depolarizing Agents
(administration & dosage)
- Nifedipine
(administration & dosage)
- Pain
(drug therapy, etiology)
- Pain Measurement
- Prostatic Neoplasms
(pathology)
- Treatment Outcome
- Ultrasonography, Interventional
|