Twenty-four-hour intraocular pressure control with the travoprost/timolol maleate fixed combination compared with travoprost when both are dosed in the evening in primary open-angle glaucoma.

Abstract

OBJECTIVE:

To evaluate the 24 h efficacy and safety of the travoprost/timolol maleate fixed combination (TTFC) versus travoprost when both are dosed in the evening in primary open-angle glaucoma patients.

METHODS:

Prospective, double-masked, crossover, active-controlled, randomised 24 h comparison. After a 6 week medicine-free period, patients were randomised to either TTFC or travoprost for 8 weeks and were then switched to the opposite treatment for another 8 weeks. At the end of the washout and treatment periods, a 24 h pressure curve was performed.

RESULTS:

Thirty-two patients completed the study. The TTFC group demonstrated a lower absolute intraocular pressure level (2.4 mm Hg) for the 24 h curve and at all time points, compared with travoprost (p</=0.047). The pressure reduction from untreated baseline was significantly different between treatments for all time points (p = 0.018). The mean 24 h pressure fluctuation was lower with TTFC (3.0 mm Hg) compared with travoprost (4.0 mm Hg, p = 0.001). No statistical difference existed between the two treatment groups for any adverse event (p>0.05).

CONCLUSIONS:

This study suggests that when both drugs are dosed in the evening the TTFC provides improved intraocular pressure reduction, compared with travoprost, over the 24 h curve and for each individual time point in primary open-angle glaucoma patients.

• Authors: A G P Konstas, D Mikropoulos, A-B Haidich, K S Ntampos, W C Stewart
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 93 Issue 4 Pg. 481-5 (Apr 2009) ISSN: 1468-2079 [Electronic] England
• PMID: 19019932 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Drug Combinations
• Cloprostenol
• Timolol
• Travoprost

Topics

• Adult
• Aged
• Antihypertensive Agents (administration & dosage, adverse effects)
• Circadian Rhythm
• Cloprostenol (administration & dosage, adverse effects, analogs & derivatives)
• Cross-Over Studies
• Double-Blind Method
• Drug Administration Schedule
• Drug Combinations
• Female
• Glaucoma, Open-Angle (drug therapy, physiopathology)
• Humans
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Timolol (administration & dosage, adverse effects)
• Travoprost
• Treatment Outcome