Abstract | OBJECTIVE: METHODS: Between 10/00 and 12/06, 25 stage I-II patients with serous endometrial cancer were treated at our institution with surgery, postoperative IVRT, and concurrent chemotherapy (CT). RESULTS: The mean age was 67 years old (range, 53-80 years). Surgery consisted of hysterectomy (TAH/BSO, 64%, LAVH/BSO, 36%), peritoneal washing, omental biopsy, and pelvic lymph-node dissection (median 14 nodes). Para-aortic node sampling was done in 88% (median, 6). IVRT median dose was 21 Gy (range, 18-21 Gy, in 3 fractions) and concurrent CT consisted of carboplatin to AUC=5 and taxol to 175 mg/m(2) given every 3 weeks for 6 cycles. CT was well tolerated with 22/25 (88%) receiving 6 cycles. Three patients received <or=5 cycles; 2 owing to physician preference (3 and 4 cycles) and 1 owing to toxicity (5 cycles). Only 1 patient (4%) had grade 3 toxicity ( abscess). Grade 2 neurotoxicity was seen in 5 patients (20%). All patients finished their IVRT as scheduled, and there was no grade 3 toxicity. With a median follow-up of 30 months, the 5-year progression-free and overall survival rate was 88%. None of the patients developed vaginal recurrence. CONCLUSIONS: Based on this study, surgical staging followed by IVRT and carboplatin/ paclitaxel is well tolerated and effective in stage I-II serous endometrial cancer. Confirmation of these results on a larger number of patients with longer follow-up is still needed.
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Authors | Kaled M Alektiar, Vicky Makker, Nadeem R Abu-Rustum, Robert A Soslow, Dennis S Chi, Richard R Barakat, Carol A Aghajanian |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 112
Issue 1
Pg. 142-5
(Jan 2009)
ISSN: 1095-6859 [Electronic] United States |
PMID | 19019418
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Carboplatin
(administration & dosage)
- Chemotherapy, Adjuvant
- Drug Administration Schedule
- Endometrial Neoplasms
(drug therapy, pathology, radiotherapy, surgery)
- Female
- Humans
- Hysterectomy
- Lymph Node Excision
- Middle Aged
- Neoplasm Staging
- Ovariectomy
- Paclitaxel
(administration & dosage)
- Radiotherapy
(methods)
- Vagina
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