Abstract | INTRODUCTION: METHODS: RESULTS: Oral T-614 inhibited paw swelling and offered significant protection against arthritis-induced cartilage and bone erosion, comparable to the effects of methotrexate. CIA rats treated with T-614 exhibited decreases in both mRNA expression of IL-17 in peripheral blood mononuclear cells and lymph node cells, and circulating IL-17 in a dose-dependent manner. T-614 also reduced serum levels of tumor necrosis factor-alpha, IL-1beta and IL-6. A synergistic effect was observed for the combination of methotrexate and T-614. In addition, T-614 (20 mg/kg per day) depressed production of anti- type II collagen antibodies and differentially affected levels of IgG2a subclasses in vivo, whereas IgM level was decreased without any change in the IgG1 level. Together, the findings presented here indicate that the novel agent T-614 has disease-modifying effects against experimental arthritis, as opposed to nimesulide. CONCLUSIONS:
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Authors | Fang Du, Liang-jing Lü, Qiong Fu, Min Dai, Jia-lin Teng, Wei Fan, Shun-le Chen, Ping Ye, Nan Shen, Xin-fang Huang, Jie Qian, Chun-de Bao |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 10
Issue 6
Pg. R136
( 2008)
ISSN: 1478-6362 [Electronic] England |
PMID | 19019215
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzopyrans
- Inflammation Mediators
- Sulfonamides
- T 614
- Methotrexate
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Topics |
- Animals
- Arthritis, Experimental
(blood, pathology, prevention & control)
- Benzopyrans
(pharmacology, therapeutic use)
- Cartilage, Articular
(drug effects, immunology, pathology)
- Drug Therapy, Combination
- Female
- Inflammation Mediators
(therapeutic use)
- Knee Joint
(drug effects, immunology, pathology)
- Methotrexate
(therapeutic use)
- Rats
- Rats, Wistar
- Sulfonamides
(pharmacology, therapeutic use)
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