Abstract | BACKGROUND: Rhesus monkeys are relevant models for human diseases. The simian immunodeficiency virus (SIV) infection is an useful macaque model for assessing human immunodeficiency virus ( HIV) vaccine strategies. Susceptibility and resistance to viruses have been associated with particular major histocompatibility complex (MHC) molecules. Several epitopes in the HIV structural and non-structural protein restricted by distinct MHC class I haplotypes are important targets for human cytotoxic T lymphocytes, which mediate protection against SIVmac infection. Mamu-A*01, for example, is a MHC class I molecule of rhesus monkeys that presents a peptide from SIV gag protein. METHODS: Our study determined the frequency of Mamu-A*01 in a closed colony of rhesus monkeys from Brazil by polymerase chain reaction. RESULTS: A high frequency of the allele was found in the study colony. CONCLUSION: This colony provides a significant source of A*01-positive animals to investigators.
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Authors | Márcia Cristina Ribeiro Andrade, José Paulo Gagliardi Leite, Pedro Hernan Cabello |
Journal | Journal of medical primatology
(J Med Primatol)
Vol. 38
Issue 1
Pg. 39-41
(Feb 2009)
ISSN: 0047-2565 [Print] Denmark |
PMID | 19018945
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Alleles
- Animals
- Brazil
- Breeding
- Female
- Gene Frequency
- Genes, MHC Class I
- Macaca mulatta
(genetics)
- Male
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