Abstract | BACKGROUND: METHODS: In 389 participants from the NETT Genetics Ancillary Study, single-nucleotide polymorphisms (SNPs) were genotyped in five candidate genes previously associated with COPD susceptibility (EPHX1, SERPINE2, SFTPB, TGFB1, and GSTP1). Linear regression models were used to test for associations among these SNPs and three quantitative COPD-related traits (Pao(2), Paco(2), and pulmonary artery systolic pressure). Genes associated with hypoxemia were tested for replication in probands from the Boston Early-Onset COPD Study. RESULTS: CONCLUSIONS: In participants with severe COPD, SNPs in EPHX1 and SERPINE2 were associated with hypoxemia in two separate study populations, and SNPs from SFTPB were associated with pulmonary artery pressure in the NETT participants.
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Authors | Peter J Castaldi, Craig P Hersh, John J Reilly, Edwin K Silverman |
Journal | Chest
(Chest)
Vol. 135
Issue 3
Pg. 737-744
(Mar 2009)
ISSN: 1931-3543 [Electronic] United States |
PMID | 19017876
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amyloid beta-Protein Precursor
- Protease Nexins
- Pulmonary Surfactant-Associated Protein B
- Receptors, Cell Surface
- SERPINE2 protein, human
- Serpin E2
- Epoxide Hydrolases
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Topics |
- Aged
- Amyloid beta-Protein Precursor
(genetics)
- Epoxide Hydrolases
(genetics)
- Female
- Humans
- Hypercapnia
(complications, genetics)
- Hypertension, Pulmonary
(complications, genetics)
- Hypoxia
(complications, genetics)
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Protease Nexins
- Pulmonary Disease, Chronic Obstructive
(complications, genetics)
- Pulmonary Surfactant-Associated Protein B
(genetics)
- Receptors, Cell Surface
(genetics)
- Serpin E2
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