Abstract | AIM OF THE STUDY: MATERIAL AND METHODS: Mice were treated orally with KIOM-79 (150 mg/kg body weight) once daily for 12 weeks. Levels of retinal ganglion cell death were measured by terminal dUTP nick-end labeling (TUNEL) assay. In the retina, the activity of caspase-3 (a marker of apoptosis) and the formation of AGEs were measured by immunohistochemical staining. RESULTS: CONCLUSIONS: These data show that KIOM-79 can prevent apoptosis in neuronal cells, AGEs accumulation in the retina, and retard the development of diabetic retinopathy.
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Authors | Eun Jin Sohn, Young Sook Kim, Chan-Sik Kim, Yun Mi Lee, Jin Sook Kim |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 121
Issue 1
Pg. 171-4
(Jan 12 2009)
ISSN: 0378-8741 [Print] Ireland |
PMID | 19013511
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Glycation End Products, Advanced
- KIOM 79
- Plant Extracts
- Casp3 protein, mouse
- Caspase 3
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Topics |
- Administration, Oral
- Animals
- Antioxidants
(pharmacology, therapeutic use)
- Apoptosis
(drug effects)
- Caspase 3
(metabolism)
- Cell Death
(drug effects)
- Diabetes Mellitus, Experimental
(metabolism, pathology, prevention & control)
- Diabetic Retinopathy
(metabolism, pathology, prevention & control)
- Disease Models, Animal
- Glycation End Products, Advanced
(antagonists & inhibitors, metabolism)
- Immunohistochemistry
- In Situ Nick-End Labeling
- Male
- Mice
- Mice, Inbred C57BL
- Plant Extracts
(pharmacology, therapeutic use)
- Retina
(drug effects, metabolism, pathology)
- Retinal Ganglion Cells
(metabolism, pathology)
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