[Super-elderly colon cancer with peritoneal dissemination effectively treated with modified FOLFOX6 chemotherapy--report of a case].

Abstract

We reported a case of super-elderly colon cancer with peritoneal dissemination effectively treated with modified FOLFOX6 chemotherapy. A 80-year-old woman was referred to our hospital for abdominal distension in January 2007. Abdominal CT showed peritoneal dissemination and colonoscopy revealed transverse colon cancer. The patient's performance status (PS) score was 3. She had pleural effusion on the left side and massive acsites. After the general condition was improved, operation was performed for sub-ileus in March, but it became a probe laparotomy for severe peritoneal dissemination. We tried modified FOLFOX6 chemotherapy from April. The patient's pleural effusion decreased after 3 courses of chemotherapy and we could remove the thoracic tube. Massive acsites observed in abdominal CT disappeared after 5 courses of chemotherapy. The patient did not suffer from sub-ileus after around 8 courses of chemotherapy and she could then take food. The patient's PS score became 1, and she was discharged in September. Two more courses of chemotherapy were given on as an outpatient basis. The chemotherapy was changed to S-1 on the patient's request in November. As of February 2008, the patient's PS score was 0, and she has been under treatment as an outpatient.

• Authors: Hideyuki Ishida, Ami Wada, Shoichiro Fujita, Yasunori Watanabe, Kazunori Nakaguchi, Toshiyuki Kabuto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 11 Pg. 1955-7 (Nov 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 19011351 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carcinoembryonic Antigen
• Organoplatinum Compounds
• Leucovorin
• Fluorouracil

Topics

• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoembryonic Antigen (blood)
• Colonic Neoplasms (blood, diagnostic imaging, drug therapy, pathology)
• Female
• Fluorouracil (therapeutic use)
• Humans
• Leucovorin (therapeutic use)
• Organoplatinum Compounds (therapeutic use)
• Peritoneal Neoplasms (blood, diagnostic imaging, drug therapy, secondary)
• Tomography, X-Ray Computed