Abstract | OBJECTIVE: METHODS AND RESULTS: Plasma was collected from patients before (pre-AP), 24 hours after (AP-1 d), and 5 days after cardiac surgery (AP-5 d). SAA levels were increased 16-fold in AP-1 d samples. The activity of sPLA(2)-IIA was increased from 77.7+/-38.3 U/mL (pre-AP) to 281.4+/-57.1 U/mL (AP-1 d; P<0.001). CETP mass and activity reduction was commensurate to the reduction of HDL cholesterol levels. The combined action of SAA, sPLA(2)-IIA, and CETP in vitro markedly remodeled HDL with the generation of lipid-poor apoA-I from both pre-AP and AP-1 d HDL. The net result of this remodeling was a relative preservation of ABCA1- and ABCG1-dependent cholesterol efflux during the acute phase response. CONCLUSIONS:
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Authors | Anisa Jahangiri, Maria C de Beer, Victoria Noffsinger, Lisa R Tannock, Chandrashekar Ramaiah, Nancy R Webb, Deneys R van der Westhuyzen, Frederick C de Beer |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 29
Issue 2
Pg. 261-7
(Feb 2009)
ISSN: 1524-4636 [Electronic] United States |
PMID | 19008529
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- ABCA1 protein, human
- ABCG1 protein, human
- APOA1 protein, human
- ATP Binding Cassette Transporter 1
- ATP Binding Cassette Transporter, Subfamily G, Member 1
- ATP-Binding Cassette Transporters
- Apolipoprotein A-I
- CETP protein, human
- Cholesterol Ester Transfer Proteins
- Lipoproteins, HDL
- Recombinant Proteins
- Serum Amyloid A Protein
- Cholesterol
- Group II Phospholipases A2
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Topics |
- ATP Binding Cassette Transporter 1
- ATP Binding Cassette Transporter, Subfamily G, Member 1
- ATP-Binding Cassette Transporters
(blood)
- Acute-Phase Reaction
(blood, etiology)
- Apolipoprotein A-I
(blood)
- Cardiac Surgical Procedures
(adverse effects)
- Cholesterol
(blood)
- Cholesterol Ester Transfer Proteins
(blood)
- Chromatography, Affinity
- Group II Phospholipases A2
(blood)
- Humans
- Lipoproteins, HDL
(blood)
- Macrophages
(metabolism)
- Recombinant Proteins
(metabolism)
- Serum Amyloid A Protein
(metabolism)
- Time Factors
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