Abstract |
Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 microM for marineosin A) and selective activities in diverse cancer cell types.
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Authors | Chollaratt Boonlarppradab, Christopher A Kauffman, Paul R Jensen, William Fenical |
Journal | Organic letters
(Org Lett)
Vol. 10
Issue 24
Pg. 5505-8
(Dec 18 2008)
ISSN: 1523-7052 [Electronic] United States |
PMID | 19007176
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Anticarcinogenic Agents
- Antifungal Agents
- Pyrroles
- Spiro Compounds
- marineosin A
- marineosin B
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Topics |
- Anticarcinogenic Agents
(chemistry, isolation & purification, pharmacology)
- Antifungal Agents
(chemistry, isolation & purification, pharmacology)
- Candida albicans
(drug effects)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Humans
- Marine Biology
- Molecular Conformation
- Pyrroles
(chemistry, isolation & purification, pharmacology)
- Spiro Compounds
(chemistry, isolation & purification, pharmacology)
- Streptomyces
(chemistry)
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