Abstract | BACKGROUND: METHODS: A total of 832 renal transplant recipients were genotyped for the CYP3A4 -288A>G, CYP3A5 +6986G>A, ABCB1 +1236C>T, +2677G>T>A, and +3435C>T polymorphisms. Their association with acute rejection and with pharmacokinetic parameters was analyzed in haplotype models. RESULTS: CONCLUSIONS: ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms. The risk of acute rejection determined by ABCB1 is independent of pharmacokinetic parameters. CYP3A haplotypes control the bioavailability of Tac, but do not modify the risk of acute rejection.
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Authors | Stepan Bandur, Jan Petrasek, Petra Hribova, Eva Novotna, Irena Brabcova, Ondrej Viklicky |
Journal | Transplantation
(Transplantation)
Vol. 86
Issue 9
Pg. 1206-13
(Nov 15 2008)
ISSN: 1534-6080 [Electronic] United States |
PMID | 19005401
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ABCB1 protein, human
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1
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Topics |
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1
(genetics, metabolism)
- Adolescent
- Adult
- Aged
- Alleles
- Case-Control Studies
- Child
- Child, Preschool
- Cohort Studies
- Female
- Genotype
- Graft Rejection
(genetics, metabolism)
- Graft Survival
(genetics)
- Haplotypes
(genetics)
- Humans
- Kidney Transplantation
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Retrospective Studies
- Risk Factors
- Transplantation, Homologous
- Young Adult
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