Aspartate carbamoyltransferase inhibition and uridylate trapping result in a synergistic depression of uridine triphosphate in hepatoma cells.

• Authors: D D Keppler
• Journal: FEBS letters (FEBS Lett) Vol. 73 Issue 2 Pg. 263-6 (Feb 01 1977) ISSN: 0014-5793 [Print] England
• PMID: 190038 (Publication Type: Journal Article)

Chemical References

• Organophosphonates
• Uracil Nucleotides
• Aspartic Acid
• Galactosamine
• Aspartate Carbamoyltransferase

Topics

• Animals
• Aspartate Carbamoyltransferase (antagonists & inhibitors)
• Aspartic Acid (pharmacology)
• Carcinoma, Hepatocellular (metabolism)
• Cells, Cultured
• Female
• Galactosamine (pharmacology)
• Kinetics
• Liver Neoplasms (metabolism)
• Neoplasms, Experimental (metabolism)
• Organophosphonates (pharmacology)
• Rats
• Uracil Nucleotides (metabolism)