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Role of bile acid secretion in human colorectal cancer.

Abstract
Cholic, deoxycholic and lithocholic acid promote tumor formation in the large intestine by a direct proliferative effect on rather undifferentiated mucosal epithelial cells. In addition, bile acids may play a role in colorectal cancer pathogenesis because they reduce the chemopreventive efficiency of calcium and vitamin D by interfering with calcium and vitamin D receptor-activated anti-mitogenic intracellular signalling in neoplastic colonocytes.
AuthorsMeinrad Peterlik
JournalWiener medizinische Wochenschrift (1946) (Wien Med Wochenschr) Vol. 158 Issue 19-20 Pg. 539-41 ( 2008) ISSN: 0043-5341 [Print] Austria
PMID18998068 (Publication Type: Journal Article)
Chemical References
  • Bile Acids and Salts
  • Receptors, Calcitriol
  • Receptors, Calcium-Sensing
  • Calcitriol
  • Calcium
Topics
  • Animals
  • Bile Acids and Salts (metabolism)
  • Calcitriol (physiology)
  • Calcium (physiology)
  • Cell Division (physiology)
  • Cell Transformation, Neoplastic (pathology)
  • Colorectal Neoplasms (pathology, physiopathology)
  • Humans
  • Intestinal Mucosa (pathology, physiopathology)
  • Mice
  • Receptors, Calcitriol (physiology)
  • Receptors, Calcium-Sensing (physiology)
  • Signal Transduction (physiology)

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