Abstract |
Cholic, deoxycholic and lithocholic acid promote tumor formation in the large intestine by a direct proliferative effect on rather undifferentiated mucosal epithelial cells. In addition, bile acids may play a role in colorectal cancer pathogenesis because they reduce the chemopreventive efficiency of calcium and vitamin D by interfering with calcium and vitamin D receptor-activated anti-mitogenic intracellular signalling in neoplastic colonocytes.
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Authors | Meinrad Peterlik |
Journal | Wiener medizinische Wochenschrift (1946)
(Wien Med Wochenschr)
Vol. 158
Issue 19-20
Pg. 539-41
( 2008)
ISSN: 0043-5341 [Print] Austria |
PMID | 18998068
(Publication Type: Journal Article)
|
Chemical References |
- Bile Acids and Salts
- Receptors, Calcitriol
- Receptors, Calcium-Sensing
- Calcitriol
- Calcium
|
Topics |
- Animals
- Bile Acids and Salts
(metabolism)
- Calcitriol
(physiology)
- Calcium
(physiology)
- Cell Division
(physiology)
- Cell Transformation, Neoplastic
(pathology)
- Colorectal Neoplasms
(pathology, physiopathology)
- Humans
- Intestinal Mucosa
(pathology, physiopathology)
- Mice
- Receptors, Calcitriol
(physiology)
- Receptors, Calcium-Sensing
(physiology)
- Signal Transduction
(physiology)
|