HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

High-dose chemotherapy followed by stem cell rescue for high-risk germ cell tumors: the Stanford experience.

Abstract
Germ cell tumors carry an excellent prognosis with platinum-based therapy upfront. The patients who either relapse or demonstrate refractoriness to platinum pose a challenge. There exist many reports in the literature on the use of high-dose chemotherapy and stem cell rescue improving the outcome in patients with relapsed germ cell tumors. However, the reports have great variability in the patient selection, prior treatments, the choice of the conditioning regimen and variability of the doses within the same regimen. In this report, we present 37 patients who underwent a uniform protocol of high-dose chemotherapy with stem cell rescue. Stem cell mobilization was performed with high-dose CY (4 g per m(2)) and we were able to collect adequate cells for marrow rescue in all patients. Patients received a high-dose regimen with etoposide (800 mg/m(2) per day) days -6, -5 and -4 as a continuous infusion, carboplatin (667 mg/m(2) per day) on days -6, -5 and -4 as a 1 h infusion, and CY (60 mg/kg per day) on days -3 and -2. In this high-risk group of patients, high-dose chemotherapy with autologous stem cell rescue led to a 3-year overall survival of 57% and a 3-year event-free survival of 49%. The results are reflective of a single procedure. No tandem transplants were performed. The treatment-related mortality was low at 3% in this heavily pretreated group.
AuthorsR Agarwal, C C Dvorak, K E Stockerl-Goldstein, L Johnston, S Srinivas
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 43 Issue 7 Pg. 547-52 (Apr 2009) ISSN: 1476-5365 [Electronic] England
PMID18997833 (Publication Type: Journal Article)
Chemical References
  • Etoposide
  • Cyclophosphamide
  • Carboplatin
Topics
  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Carboplatin (administration & dosage)
  • Child
  • Combined Modality Therapy
  • Cyclophosphamide (administration & dosage)
  • Disease-Free Survival
  • Etoposide (administration & dosage)
  • Female
  • Hematopoietic Stem Cell Mobilization
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells (pathology)
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Germ Cell and Embryonal (drug therapy, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: