Abstract | PURPOSE: METHODS: RESULTS: CONCLUSIONS: Combined with previous reports, these data suggest that retinal degenerations are associated with altered iron homeostasis regardless of the primary insult. Given the potential of iron to generate oxidative injury, its role as a therapeutic target in retinal and macular degenerations should be evaluated.
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Authors | Efrat Deleon, Michal Lederman, Eddy Berenstein, Tal Meir, Mordechai Chevion, Itay Chowers |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 50
Issue 3
Pg. 1360-5
(Mar 2009)
ISSN: 1552-5783 [Electronic] United States |
PMID | 18997094
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ccr2 protein, mouse
- RNA, Messenger
- Receptors, CCR2
- Receptors, Transferrin
- Transferrin
- Ferritins
- Iron
- Ceruloplasmin
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Topics |
- Animals
- Blotting, Western
- Ceruloplasmin
(genetics)
- Enzyme-Linked Immunosorbent Assay
- Ferritins
(metabolism)
- Fluorescent Antibody Technique, Indirect
- Gene Expression
- Gene Silencing
- Homeostasis
- Iron
(metabolism)
- Iron Metabolism Disorders
(metabolism)
- Mice
- Mice, Inbred C57BL
- RNA, Messenger
(metabolism)
- Receptors, CCR2
(genetics)
- Receptors, Transferrin
(genetics)
- Retinal Degeneration
(genetics, metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Transferrin
(genetics)
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