Expression of 17beta-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: a correlation to clinicopathological parameters.

Abstract

Estrogens play an important role in the development and progression of breast cancer. 17beta-Hydroxysteroid dehydrogenase (17beta-HSD) type 2 and type 5 are involved in sex steroid metabolism. 17beta-HSD type 2 converts estradiol to estrone while 17beta-HSD type 5 converts androstenedione to testosterone. Using immunocytochemistry, we have studied the expression of 17beta-HSD type 2 and type 5 in 50 specimens of breast carcinoma and adjacent non-malignant tissues. The results were correlated with the estrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PRA) and B (PRB), androgen receptor and CDC47 and with the tumor stage, tumor size, nodal status and menopausal status. 17beta-HSD type 2 was expressed in 20% and 17beta-HSD type 5 in 56% of breast cancer specimens. In adjacent normal tissues, both enzymes were highly expressed in almost all the patients. No significant association could be found between the expression of 17beta-HSD type 2 and 17beta-HSD type 5 and between the expression of each enzyme and the clinicopathological parameters studied. The decrease in 17beta-HSD type 2 and 17beta-HSD type 5 expressions in breast cancer may play a predominant role in the development and/or progression of the cancer by modifying the intratumoral levels of estrogens and androgens.

• Authors: B Han, S Li, D Song, D Poisson-Paré, G Liu, V Luu-The, J Ouellet, S Li, F Labrie, G Pelletier
• Journal: The Journal of steroid biochemistry and molecular biology (J Steroid Biochem Mol Biol) Vol. 112 Issue 4-5 Pg. 194-200 (Dec 2008) ISSN: 0960-0760 [Print] England
• PMID: 18996480 (Publication Type: Journal Article)

Chemical References

• Estrogen Receptor alpha
• Estrogen Receptor beta
• Receptors, Androgen
• Receptors, Progesterone
• progesterone receptor A
• progesterone receptor B
• 17-Hydroxysteroid Dehydrogenases
• 3-Hydroxysteroid Dehydrogenases
• Hydroxyprostaglandin Dehydrogenases
• AKR1C3 protein, human
• Aldo-Keto Reductase Family 1 Member C3
• Estradiol Dehydrogenases
• HSD17B2 protein, human

Topics

• 17-Hydroxysteroid Dehydrogenases (biosynthesis)
• 3-Hydroxysteroid Dehydrogenases
• Adult
• Aged
• Aldo-Keto Reductase Family 1 Member C3
• Animals
• Breast (enzymology)
• Breast Neoplasms (enzymology, pathology)
• Estradiol Dehydrogenases
• Estrogen Receptor alpha (biosynthesis)
• Estrogen Receptor beta (biosynthesis)
• Female
• Humans
• Hydroxyprostaglandin Dehydrogenases
• Middle Aged
• Rabbits
• Receptors, Androgen (biosynthesis)
• Receptors, Progesterone (biosynthesis)