Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines.

Abstract

Phytochemical investigation of the roots of Ferula elaeochytris made it possible to isolate two sesquiterpene esters, 6-anthraniloyljaeschkeanadiol (elaeochytrin A) and 4beta-hydroxy-6alpha-(p-hydroxybenzoyloxy)dauc-9-ene (elaeochytrin B), as well as eight known compounds: 6-angeloyljaeschkeanadiol, teferidin, ferutinin, 6-(p-hydroxybenzoyl)epoxyjaeschkeanadiol, 6-(p-hydroxybenzoyl)lancerotriol, 5-caffeoylquinic acid, 1,5-dicaffeoylquinic acid and sandrosaponin IX. The cytotoxic activities of all compounds were investigated on K562R (imatinib-resistant) human chronic myeloid leukaemia and DA1-3b/M2(BCR-ABL) (dasatinib-resistant) mouse leukemia cell line. Elaeochytrin A was the most active compound on both cell lines (IC(50)=12.4 and 7.8microM, respectively). It was also tested on non-resistant human promyelocytic leukemia cells (HL60, IC(50)=13.1microM) and was not toxic to normal peripheral blood mononuclear cells up to 100microM.

• Authors: Racha Alkhatib, Thierry Hennebelle, Sami Joha, Thierry Idziorek, Claude Preudhomme, Bruno Quesnel, Sevser Sahpaz, François Bailleul
• Journal: Phytochemistry (Phytochemistry) Vol. 69 Issue 17 Pg. 2979-83 (Dec 2008) ISSN: 0031-9422 [Print] England
• PMID: 18992904 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Sesquiterpenes
• elaeochytrin A

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Ferula (chemistry, metabolism)
• Humans
• Leukemia (drug therapy)
• Mice
• Molecular Structure
• Plant Roots (chemistry, metabolism)
• Sesquiterpenes (chemistry, metabolism, pharmacology)