Abstract | UNLABELLED: RESULTS: The data obtained evidence that at monotherapy most pronounced lowering of arterial pressure is observed during use of verapamil CR or amlodipine. Therapy with all studied drugs led to significant decrease of number of episodes of ST-segment depressions, their duration and amplitude during 24 hours. Greatest decrease of frequency of episodes of ST-segment depression was observed during therapy with heart rate reducing calcium antagonists. Disturbed LV diastolic function improved under action of calcium antagonists and beta-adrenoblockers did not change during therapy with angiotensin converting enzyme inhibitor. Diminishment of severity of disturbance of diastolic function under influence of pulse slowing calcium antagonists was associated in the first place with augmentation of LV filling in the first phase of diastole, but during therapy with amlodipine and beta-adrenoblockers - with decrease of contribution of systole of the left atrium. beta-adrenoblockers and diltiazem improved LV diastolic function in patients with episodes of painless myocardial ischemia. CONCLUSION: Comparative assessment of hypotensive action of preparations from three groups revealed that greatest lowering of arterial pressure occurred during monotherapy with verapamil SR and amlodipine. The stadied drugs differently affected damage of a target organ - the heart - in patients with AH.
|
Authors | N A Mazur, O N Lazareva |
Journal | Kardiologiia
(Kardiologiia)
Vol. 48
Issue 10
Pg. 4-9
( 2008)
ISSN: 0022-9040 [Print] Russia (Federation) |
PMID | 18991827
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Calcium Channel Blockers
|
Topics |
- Adrenergic beta-Antagonists
(pharmacology, therapeutic use)
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology, therapeutic use)
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Blood Pressure
(drug effects)
- Calcium Channel Blockers
(pharmacology, therapeutic use)
- Female
- Humans
- Hypertension
(drug therapy, epidemiology)
- Male
- Middle Aged
- Myocardial Ischemia
(drug therapy, epidemiology)
- Pain
(diagnosis, epidemiology)
- Severity of Illness Index
- Ventricular Function, Left
(drug effects)
|