Abstract | OBJECTIVE: To investigate the effects of Xuefu Zhuyu Oral Liquid, a compound traditional Chinese herbal medicine for resolving stagnation, on hemorheology in the patients with blood-stasis syndrome due to coronary disease and their relationship with human platelet antigen-3 (HPA-3) polymorphism of membrane glycoprotein IIb (GPIIb). METHODS: Thirty-two patients with blood-stasis syndrome due to coronary disease were selected in this study. Blood-stasis syndrome scoring was performed and hemorheological parameters were measured in all subjects before and after Xuefu Zhuyu Qral Liquid treatment. The genotypes of GPIIb HPA-3 were determined by TaqMan probe technology. RESULTS: The hemorheology was improved in the patients with blood-stasis syndrome due to coronary heart disease after the treatment. There were significant differences in the whole blood viscosity, deformation index of red blood cells and scores of blood-stasis syndrome between the patients carrying AC plus CC and the patients carrying AA after the treatment (P<0.05). CONCLUSION:
Xuefu Zhuyu Oral Liquid can improve clinical symptoms and hemorheology in the patients with blood-stasis syndrome due to coronary heart disease, which is related to GPIIb HPA-3 polymorphism.
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Authors | Mei Xue, Ke-ji Chen, Xiao-juan Ma, Jian-gang Liu, Yue-rong Jiang, Yu Miao, Hui-jun Yin |
Journal | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
(Zhong Xi Yi Jie He Xue Bao)
Vol. 6
Issue 11
Pg. 1129-35
(Nov 2008)
ISSN: 1672-1977 [Print] China |
PMID | 18990338
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Human Platelet
- Drugs, Chinese Herbal
- Platelet Membrane Glycoprotein IIb
- Xue-Fu-Zhu-Yu decoction
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Topics |
- Aged
- Antigens, Human Platelet
(genetics)
- Coronary Disease
(blood, drug therapy, genetics)
- Drugs, Chinese Herbal
(therapeutic use)
- Female
- Genotype
- Hemorheology
(drug effects)
- Humans
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Platelet Membrane Glycoprotein IIb
(genetics)
- Polymorphism, Genetic
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