Abstract | UNLABELLED: METHODS:
Irsogladine 2-4 mg/day was administered orally to ten BD patients (cases 1-10), three men and seven women, with a mean age of 48.5 years, with recurrent aphthous stomatitis as the main symptom. Pre-existing treatments were not changed. All patients were followed up at our outpatient clinic once a month. The patients had no systemic neurological, gastrointestinal or vascular symptoms. Efficacy was evaluated on the basis of the macroscopic findings of aphthous lesions. We counted the number of aphthous lesions three times prior to administration of irsogladine and three times after treatment at the outpatient clinic, i.e. six times in total, and compared pre- and post-treatment mean numbers of lesions for each patient. RESULTS: CONCLUSION:
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Authors | Yuki Nanke, Naoyuki Kamatani, Toshihiro Okamoto, Hideki Ogiuchi, Shigeru Kotake |
Journal | Drugs in R&D
(Drugs R D)
Vol. 9
Issue 6
Pg. 455-9
( 2008)
ISSN: 1174-5886 [Print] New Zealand |
PMID | 18989994
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Triazines
- irsogladine
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Topics |
- Administration, Oral
- Adult
- Anti-Ulcer Agents
(pharmacology, therapeutic use)
- Behcet Syndrome
(drug therapy, physiopathology)
- Cell Communication
(drug effects)
- Female
- Follow-Up Studies
- Gap Junctions
(drug effects)
- Humans
- Male
- Middle Aged
- Recurrence
- Stomatitis, Aphthous
(drug therapy, etiology)
- Triazines
(pharmacology, therapeutic use)
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