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Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers.

Abstract
This observation reports that a hepatitis B virus (HBV) reactivation, as the result of hepatitis C virus (HCV) eradication on a dominant HCV coinfected HBV/HCV patient, was subsequently prevented by treating both viral infections together. This finding raises the question as to whether preemptive HBV treatment should be prescribed along with HCV treatment to prevent HBV from being reactive after HCV eradication in coinfected HBV/HCV patients.
AuthorsChristophe Renou, Jean-François Cadranel, Alexandre Pariente, Guillaume Pénaranda, Marc Bourlière, Philippe Halfon, Jean-Pierre Igual, Abdelouahid Harafa, Pierre Muller, Jean-Jacques Bertrand, René Laugier
JournalEuropean journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 20 Issue 12 Pg. 1235-7 (Dec 2008) ISSN: 1473-5687 [Electronic] England
PMID18989147 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiviral Agents
  • Organophosphonates
  • adefovir
  • Adenine
Topics
  • Adenine (analogs & derivatives, therapeutic use)
  • Adult
  • Antiviral Agents (therapeutic use)
  • Carrier State (drug therapy, virology)
  • Drug Therapy, Combination
  • Hepatitis B (complications, drug therapy, prevention & control)
  • Hepatitis B virus (drug effects, physiology)
  • Hepatitis C (complications, drug therapy)
  • Humans
  • Male
  • Organophosphonates (therapeutic use)
  • Virus Activation (drug effects)

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