Abstract |
The streptovaricin complex (SvCx) and rifamycin SV derivatives display potent antiviral activity against the polycythemic strain of Friend leukemia virus (FV-P), as measured by a reduction in the number of spleen foci produced in mice. Such reductions may be explained by inactivation of functions of (i) the spleen focus-forming virus (SFFV), (ii) its "helper" murine leukemia virus (MuLV), or (iii) both viruses normally present in FV-P. We noted that preincubation of FV-P with fractionation products of SvCx, or derivatives of rifamycin SV, at low concentrations (3 to 5 mug/ml) reduces the number of spleen foci 80 to 97%, whereas titers of MuLV (from the same inoculum) remain unaffected (MuLV titers were measured by XC, S(+)L(-), and "helper activity" assays). Our findings indicate a remarkable biological selectivity of ansamycins, as well as nonansamycin components of SvCx, against the transforming and defective spleen focus-forming virus as compared to MuLV. Thus, the drugs might be useful in distinguishing other types of oncornaviruses.
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Authors | J S Horoszewicz, S S Leong, W A Carter |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 12
Issue 1
Pg. 4-10
(Jul 1977)
ISSN: 0066-4804 [Print] United States |
PMID | 18986
(Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Rifamycins
- Viral Proteins
- Streptovaricin
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Topics |
- Animals
- Cell Line
- Female
- Friend murine leukemia virus
(drug effects, radiation effects)
- Leukemia Virus, Murine
(drug effects, radiation effects)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Rifamycins
(pharmacology)
- Streptovaricin
(pharmacology)
- Ultraviolet Rays
- Viral Proteins
(pharmacology)
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