Abstract |
The effect of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone ( gamma-ABT) on local and systemic changes of rats with adjuvant induced disease (AID) was investigated, gamma-ABT showed potent inhibitory effect on adjuvant primary inflammation and almost totally inhibited the secondary lesions. gamma-ABT improved the changes in lymphoid organ weight except of the thymus. gamma-ABT improved the change in albumin/ globulin ratio, which is a parameter of systemic inflammatory reaction but did not improve the body weight gain in AID and normal rats. In addition gamma-ABT did not affect directly T or B lymphocytes as shown by the lymphocyte responses to mitogen (Con A) and a T cell dependent antigen (SRBC) but rather inhibited the suppressor cells found in AID. Although structurally gamma-ABT is completely different from known non-steroidal anti-inflammatories, immunosuppressive drugs behave to a great extent like them.
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Authors | L Kourounakis, A Gavalas, E E Karagouni, D Litina, P Kourounakis |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 41
Issue 5
Pg. 537-41
(May 1991)
ISSN: 0004-4172 [Print] Germany |
PMID | 1898425
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Immunologic
- Anti-Inflammatory Agents, Non-Steroidal
- Liver Glycogen
- Mitogens
- Thiophenes
- Concanavalin A
- gamma-(2-aminoethylamino)-2-butryothienone
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Topics |
- Adjuvants, Immunologic
(pharmacology)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Antibody Formation
(drug effects)
- Antibody-Producing Cells
(drug effects)
- Arthritis, Experimental
(drug therapy, pathology)
- B-Lymphocytes
(drug effects)
- Body Weight
(drug effects)
- Concanavalin A
(pharmacology)
- Female
- Foot
(pathology)
- Liver Glycogen
(metabolism)
- Male
- Mitogens
- Mycobacterium
- Rats
- Rats, Inbred F344
- T-Lymphocytes
(drug effects)
- Thiophenes
(pharmacology)
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