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Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 2nd communication: inhibitory effect on rat adjuvant induced disease.

Abstract
The effect of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone (gamma-ABT) on local and systemic changes of rats with adjuvant induced disease (AID) was investigated, gamma-ABT showed potent inhibitory effect on adjuvant primary inflammation and almost totally inhibited the secondary lesions. gamma-ABT improved the changes in lymphoid organ weight except of the thymus. gamma-ABT improved the change in albumin/globulin ratio, which is a parameter of systemic inflammatory reaction but did not improve the body weight gain in AID and normal rats. In addition gamma-ABT did not affect directly T or B lymphocytes as shown by the lymphocyte responses to mitogen (Con A) and a T cell dependent antigen (SRBC) but rather inhibited the suppressor cells found in AID. Although structurally gamma-ABT is completely different from known non-steroidal anti-inflammatories, immunosuppressive drugs behave to a great extent like them.
AuthorsL Kourounakis, A Gavalas, E E Karagouni, D Litina, P Kourounakis
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 41 Issue 5 Pg. 537-41 (May 1991) ISSN: 0004-4172 [Print] GERMANY
PMID1898425 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Anti-Inflammatory Agents, Non-Steroidal
  • Liver Glycogen
  • Mitogens
  • Thiophenes
  • Concanavalin A
  • gamma-(2-aminoethylamino)-2-butryothienone
Topics
  • Adjuvants, Immunologic (pharmacology)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Antibody Formation (drug effects)
  • Antibody-Producing Cells (drug effects)
  • Arthritis, Experimental (drug therapy, pathology)
  • B-Lymphocytes (drug effects)
  • Body Weight (drug effects)
  • Concanavalin A (pharmacology)
  • Female
  • Foot (pathology)
  • Liver Glycogen (metabolism)
  • Male
  • Mitogens
  • Mycobacterium
  • Rats
  • Rats, Inbred F344
  • T-Lymphocytes (drug effects)
  • Thiophenes (pharmacology)

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