Abstract | BACKGROUND: METHODS: In this study, we compare the anti-angiogenic properties of endostatin and anastellin using cell proliferation and transwell migration assays. RESULTS: CONCLUSION: These data indicate that anastellin and endostatin exert their anti-angiogenic effects by modulating distinct steps in the angiogenic pathway and suggest that matrix-derived inhibitors of angiogenesis may exhibit higher efficacy when used in combination.
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Authors | David M Neskey, Anthony Ambesi, Kevin M Pumiglia, Paula J McKeown-Longo |
Journal | Journal of experimental & clinical cancer research : CR
(J Exp Clin Cancer Res)
Vol. 27
Pg. 61
(Nov 04 2008)
ISSN: 1756-9966 [Electronic] England |
PMID | 18983664
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Angiogenesis Inhibitors
- Endostatins
- Fibronectins
- Peptide Fragments
- anastellin
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Topics |
- Angiogenesis Inhibitors
(pharmacology)
- Cell Proliferation
- Endostatins
(pharmacology)
- Endothelial Cells
(metabolism)
- Fibronectins
(pharmacology)
- Humans
- MAP Kinase Signaling System
- Neovascularization, Pathologic
(metabolism)
- Peptide Fragments
(pharmacology)
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