Imbalanced distribution of GM immunoglobulin allotypes according to the clinical presentation of Plasmodium falciparum malaria in Beninese children.

Abstract

Selection pressure exerted by pathogens contributes to the persistence of polymorphisms in GM and KM allotypes, which are antigenic determinants of immunoglobulins. This study investigated the impact of GM and KM allotypes on the clinical response to Plasmodium falciparum infection among Beninese children, including 65 with severe malaria, 37 with uncomplicated malaria, and 53 with asymptomatic carriage. An inverse relationship was found between the GM 5,6,13,14; 1,17 phenotype and uncomplicated malaria. Genetic markers implicated in the composition and activity of immunoglobulins may be associated with the genetic control of both malaria infection and morbidity.

• Authors: Florence Migot-Nabias, Julien M Noukpo, Evelyne Guitard, Justin Doritchamou, André Garcia, Jean-Michel Dugoujon
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 198 Issue 12 Pg. 1892-5 (Dec 15 2008) ISSN: 0022-1899 [Print] United States
• PMID: 18983245 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin Gm Allotypes

Topics

• Adolescent
• Animals
• Benin (epidemiology)
• Child
• Child, Preschool
• Genetic Predisposition to Disease
• Humans
• Immunoglobulin Gm Allotypes (genetics)
• Infant
• Malaria, Falciparum (epidemiology, genetics)
• Plasmodium falciparum