Abstract |
This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.
|
Authors | Elena Roza Motrescu, Marie-Christine Rio |
Journal | Biological chemistry
(Biol Chem)
Vol. 389
Issue 8
Pg. 1037-41
(Aug 2008)
ISSN: 1431-6730 [Print] Germany |
PMID | 18979628
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- Matrix Metalloproteinase 11
|
Topics |
- Adipocytes
(enzymology)
- Animals
- Cell Communication
- Disease Progression
- Humans
- Matrix Metalloproteinase 11
(metabolism)
- Neoplasm Staging
- Neoplasms
(enzymology, pathology)
|