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Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle.

Abstract
This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.
AuthorsElena Roza Motrescu, Marie-Christine Rio
JournalBiological chemistry (Biol Chem) Vol. 389 Issue 8 Pg. 1037-41 (Aug 2008) ISSN: 1431-6730 [Print] Germany
PMID18979628 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Matrix Metalloproteinase 11
Topics
  • Adipocytes (enzymology)
  • Animals
  • Cell Communication
  • Disease Progression
  • Humans
  • Matrix Metalloproteinase 11 (metabolism)
  • Neoplasm Staging
  • Neoplasms (enzymology, pathology)

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