Abstract | OBJECTIVE: This study was conducted to confirm the absence of immune interference of 2 doses of RIX4414 ( Rotarix) on routine infant vaccinations in the United States. STUDY DESIGN: RESULTS: Antibody responses to all antigens were similar in infants in both the Co-ad and Sep-ad groups. Seroprotective antibody concentrations against diphtheria, tetanus, hepatitis B, and poliovirus types 1, 2, and 3 were achieved by >or=97.9% of the infants in both groups. Antipolyribosyl ribitol phosphate antibody levels of >or=1.0 microg/mL were achieved by 88.3% to 89.4% of infants in both groups. In both groups, >or=97.8% of the infants were seropositive for antipertussis antibodies and the 7 pneumococcal serotypes. Predefined criteria for noninferiority between groups were reached for all antigens. CONCLUSIONS: Two doses of RIX4414 coadministered with routine infant vaccines as recommended in the United States ( DTaP-HBV-IPV, PCV7, and Hib) did not impair the immune response to any of the coadministered antigens.
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Authors | Penelope H Dennehy, Helen R Bertrand, Peter E Silas, Silvia Damaso, Leonard R Friedland, Remon Abu-Elyazeed |
Journal | Pediatrics
(Pediatrics)
Vol. 122
Issue 5
Pg. e1062-6
(Nov 2008)
ISSN: 1098-4275 [Electronic] United States |
PMID | 18977955
(Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
- Hepatitis B Vaccines
- Heptavalent Pneumococcal Conjugate Vaccine
- Meningococcal Vaccines
- PEDIARIX
- Pneumococcal Vaccines
- Poliovirus Vaccine, Inactivated
- RIX4414 vaccine
- Rotavirus Vaccines
- Tetanus Toxoid
- Vaccines, Attenuated
- Vaccines, Combined
- Vaccines, Conjugate
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Topics |
- Diphtheria-Tetanus-Pertussis Vaccine
- Female
- Haemophilus Vaccines
(administration & dosage)
- Hepatitis B Vaccines
- Heptavalent Pneumococcal Conjugate Vaccine
- Humans
- Immunization Schedule
- Infant
- Male
- Meningococcal Vaccines
(administration & dosage)
- Pneumococcal Vaccines
(administration & dosage)
- Poliovirus Vaccine, Inactivated
- Rotavirus Vaccines
- Tetanus Toxoid
(administration & dosage)
- United States
- Vaccines, Attenuated
(administration & dosage)
- Vaccines, Combined
(administration & dosage)
- Vaccines, Conjugate
(administration & dosage)
- Viral Interference
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