HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparative evaluation of cytotoxicity and phototoxicity of mono and diacylglycerol amino acid-based surfactants.

Abstract
Extensive efforts have been made, recently, to find surfactants with lower irritancy potential than those presently commercially employed in pharmaceutical and cosmetic preparations. Cytotoxic and phototoxic effects of novel mono and diacylglycerol amino acid-based surfactants (glutamic acid, or arginine) were evaluated. All tested surfactants showed a clear concentration-response relationship to two immortalized cell lines, murine fibroblast cell line, 3T3, and one human keratinocyte cell line, HaCaT, demonstrated by and decrease of NR uptake. Concentrations resulting in 50% inhibition of NR uptake (IC(50)) range from 30 to 300microgmL(-1). The potential phototoxicity which could result in irritant products, was determined by modulated cytotoxicity via the resazurin reduction to resorufin and neutral red uptake (NRU) endpoints. Surfactants with two chains showed, in general, less cytotoxic but higher phototoxic effect than surfactants with only one chain.
AuthorsMaría Pilar Vinardell, Tomas Benavides, Montserrat Mitjans, María Rosa Infante, Pere Clapés, Richard Clothier
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 46 Issue 12 Pg. 3837-41 (Dec 2008) ISSN: 0278-6915 [Print] England
PMID18977405 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amino Acids
  • Diglycerides
  • Glycerides
  • Irritants
  • Surface-Active Agents
Topics
  • 3T3 Cells
  • Amino Acids (chemistry, pharmacology, toxicity)
  • Animals
  • Cell Survival (drug effects)
  • Dermatitis, Phototoxic (pathology, prevention & control)
  • Diglycerides (chemistry, pharmacology, toxicity)
  • Fibroblasts (drug effects)
  • Glycerides (chemistry, pharmacology, toxicity)
  • Humans
  • Irritants (toxicity)
  • Keratinocytes (drug effects)
  • Mice
  • Structure-Activity Relationship
  • Surface-Active Agents (chemistry, pharmacology, toxicity)
  • Ultraviolet Rays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: