Fatty acid binding proteins in adipose tissue: a promising link between metabolic syndrome and atherosclerosis?

Abstract

Adipocyte/macrophage fatty acid binding protein (A-FABP) has been shown to be closely associated with metabolic syndrome, obesity and development of atherosclerosis. Moreover, A-FABP has been recently suggested as a potential therapeutic target of these abnormalities in animal models. The present review aims to summarize current knowledge on A-FABP functions and regulations both in animal models and humans, since the role of A-FABP in human physiology and disease has not been presently clarified.

• Authors: Eva Krusinová, Terezie Pelikánová
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 82 Suppl 2 Pg. S127-34 (Dec 15 2008) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 18977052 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Fatty Acid-Binding Proteins

Topics

• Adipose Tissue (metabolism)
• Animals
• Atherosclerosis (metabolism)
• Fatty Acid-Binding Proteins (metabolism, physiology)
• Humans
• Metabolic Syndrome (metabolism)